Relationship between serum Nesfatin-1, Adiponectin, Resistin Concentration, and Obesity with Type 2 Diabetes Mellitus

Diabetes mellitus caused by insulin resistance is prompted obesity. Neuropeptide Nesfatin-1 was identified in several organs, including the central nervous system and pancreatic islet cells. peptide appears to be involved hypothalamic circuits that energy homeostasis control food intake. Adiponectin a plasma collagen-like protein produced adipocytes have been linked development of (IR), diabetes type 2 (DMT2), cardiovascular disease (CVD). Resistin first as an adipose tissue–specific hormone obesity diabetes. The aim this study estimate relationship between human serum nesfatin-1, adiponectin, resistin concentration, with T2DM. results show significant increase neisfatin-1 levels obese diabetic group compared non-obese group. had highly decrease Serum some variables, there positive correlation (BMI, insulin, HOMA-IR), WC, TG, HOMA-IR).On other hand, negative adiponectin HOMA-IR). present suggest nesftin-1 may role controlling intake well IR patients.